- Scott Michael Morgan (2 movies)
- Scott Perry (2 movies)
- Scott Shepherd (2 movies)
- Scott Spiegel (2 movies)
- Scottie Thompson (2 movies)
- Sean Avery (2 movies)
- Sean Biggerstaff (2 movies)
- Sean Bridgers (2 movies)
- Sean Cameron Michael (2 movies)
- Sean Cronin (2 movies)
- Sean Gildea (2 movies)
- Sean Lawlor (2 movies)
- Sean Meehan (2 movies)
- Sean Whalen (2 movies)
- Sebastian Blunt (2 movies)
- Sebastian Hülk (2 movies)
- Sebastien Torkia (2 movies)
- Selena Anduze (2 movies)
- Selenis Leyva (2 movies)
- Senta Moses (2 movies)
- Serge Christianssens (2 movies)
- Serge Houde (2 movies)
- Sergei Polunin (2 movies)
- Sergej Onopko (2 movies)
- Sergi Constance (2 movies)
- Sergio Briones (2 movies)
- Seth MacFarlane (2 movies)
- Shad Gaspard (2 movies)
- Shade Rupe (2 movies)
- Shahadi Wright Joseph (2 movies)
- Shakriya Tarinyawat (2 movies)
- Shamier Anderson (2 movies)
- Shane Black (2 movies)
- Shane Edelman (2 movies)
- Shane Jacobson (2 movies)
- Shane Rimmer (2 movies)
- Shane Thompson (2 movies)
- Shannon Frank (2 movies)
- Shannyn Sossamon (2 movies)
- Shaquille O'Neal (2 movies)
- Shari Headley (2 movies)
- Sharon Bajer (2 movies)
- Sharon Horgan (2 movies)
- Sharon Omi (2 movies)
- Sharon Rooney (2 movies)
- Sharon Wilkins (2 movies)
- Shaun Duke (2 movies)
- Shaunette Renée Wilson (2 movies)
- Shawn-Caulin Young (2 movies)
- Shea Adams (2 movies)