- Sergi Constance (2 movies)
- Sergio Briones (2 movies)
- Seth MacFarlane (2 movies)
- Shad Gaspard (2 movies)
- Shade Rupe (2 movies)
- Shahadi Wright Joseph (2 movies)
- Shakriya Tarinyawat (2 movies)
- Shamier Anderson (2 movies)
- Shane Black (2 movies)
- Shane Edelman (2 movies)
- Shane Jacobson (2 movies)
- Shane Rimmer (2 movies)
- Shane Thompson (2 movies)
- Shannon Frank (2 movies)
- Shannyn Sossamon (2 movies)
- Shaquille O'Neal (2 movies)
- Shari Headley (2 movies)
- Sharon Bajer (2 movies)
- Sharon Horgan (2 movies)
- Sharon Omi (2 movies)
- Sharon Rooney (2 movies)
- Sharon Wilkins (2 movies)
- Shaun Duke (2 movies)
- Shaunette Renée Wilson (2 movies)
- Shawn-Caulin Young (2 movies)
- Shea Adams (2 movies)
- Sheila Allen (2 movies)
- Sheila Houlahan (2 movies)
- Sheila M. Lockhart (2 movies)
- Shelby Zemanek (2 movies)
- Sheryl Lee (2 movies)
- Shohreh Aghdashloo (2 movies)
- Shoko Rice (2 movies)
- Shondrella Avery (2 movies)
- Shu Lan Tuan (2 movies)
- Shun Sugata (2 movies)
- Sid Sagar (2 movies)
- Silvano Marchetto (2 movies)
- Simon Callow (2 movies)
- Simon Helberg (2 movies)
- Simon Kunz (2 movies)
- Simon London (2 movies)
- Simon Reithner (2 movies)
- Simon Reynolds (2 movies)
- Simon Rhee (2 movies)
- Simon Russell Beale (2 movies)
- Sinéad Phelps (2 movies)
- Siobhan Fallon (2 movies)
- Siobhan Fallon Hogan (2 movies)
- Slaine (2 movies)