- Samuel L. Jackson (38 movies)
- Stan Lee (29 movies)
- Scarlett Johansson (17 movies)
- Stellan Skarsgård (17 movies)
- Simon Pegg (15 movies)
- Sigourney Weaver (14 movies)
- Steve Buscemi (13 movies)
- Sandra Bullock (10 movies)
- Sean Bean (10 movies)
- Sebastian Stan (9 movies)
- Seth Green (9 movies)
- Stanley Tucci (9 movies)
- Stephen Tobolowsky (9 movies)
- Sam Rockwell (8 movies)
- Sala Baker (7 movies)
- Salma Hayek (7 movies)
- Sam Neill (7 movies)
- Sylvester Stallone (7 movies)
- Sam Claflin (6 movies)
- Sam Shepard (6 movies)
- Scott Glenn (6 movies)
- Sean Astin (6 movies)
- Seth Rogen (6 movies)
- Shia LaBeouf (6 movies)
- Stephen Dunlevy (6 movies)
- Steve Park (6 movies)
- Steve Zahn (6 movies)
- Sally Field (5 movies)
- Sarah Silverman (5 movies)
- Scoot McNairy (5 movies)
- Scott Menville (5 movies)
- Sean Young (5 movies)
- Sharon Washington (5 movies)
- Shirley Henderson (5 movies)
- Stephen Graham (5 movies)
- Stephen Root (5 movies)
- Steve Carell (5 movies)
- Sacha Baron Cohen (4 movies)
- Sam Elliott (4 movies)
- Sam Hargrave (4 movies)
- Sanaa Lathan (4 movies)
- Sandra Ellis Lafferty (4 movies)
- Sandy Martin (4 movies)
- Sasha Barrese (4 movies)
- Sayed Badreya (4 movies)
- Sean Gunn (4 movies)
- Seann William Scott (4 movies)
- Sela Ward (4 movies)
- Sharon Stone (4 movies)
- Shawnee Smith (4 movies)