- Orlando Bloom (11 movies)
- Owen Wilson (8 movies)
- Octavia Spencer (7 movies)
- Oliver Platt (6 movies)
- Oscar Isaac (6 movies)
- Omar Sy (5 movies)
- Odette Annable (4 movies)
- Ola G. Furuseth (4 movies)
- Olek Krupa (4 movies)
- Oliver Phelps (4 movies)
- Ophelia Lovibond (4 movies)
- Óscar Jaenada (4 movies)
- Owen Teague (4 movies)
- O-Lan Jones (3 movies)
- Oleg Taktarov (3 movies)
- Olga Kurylenko (3 movies)
- Oliver Ford Davies (3 movies)
- Olivia Colman (3 movies)
- Olivia Wilde (3 movies)
- Olivia Williams (3 movies)
- Omar Doom (3 movies)
- Omid Djalili (3 movies)
- Otis Winston (3 movies)
- Otto Jespersen (3 movies)
- Ousaun Elam (3 movies)
- O.J. Simpson (2 movies)
- Oakley Lehman (2 movies)
- Obba Babatundé (2 movies)
- Odessa Young (2 movies)
- Ola Ray (2 movies)
- Ólafur Darri Ólafsson (2 movies)
- Olaniyan Thurmon (2 movies)
- Oliver Cooper (2 movies)
- Olivia Burnette (2 movies)
- Olivier Richters (2 movies)
- Omar Capra (2 movies)
- Omar J. Dorsey (2 movies)
- Omari Hardwick (2 movies)
- Oona Laurence (2 movies)
- Oprah Winfrey (2 movies)
- Orestes Matacena (2 movies)
- Orlando Jones (2 movies)
- Orson Bean (2 movies)
- Osy Ikhile (2 movies)
- Owen Burke (2 movies)
- Oz Perkins (2 movies)
- O'Clair Alexander (1 movie)
- O'Neal Compton (1 movie)
- O'Shea Jackson Jr. (1 movie)
- O.T. Fagbenle (1 movie)