A rare mutation has occurred within the vampire community – The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires.
When Blade’s mother was bitten by a vampire during pregnancy, she did not know that she gave her son a special gift while dying: All the good vampire attributes in combination with the best human skills. Blade and his mentor Whistler battle an evil vampire rebel (Deacon Frost) who plans to take over the outdated vampire council, capture Blade and resurrect voracious blood god La Magra.