In 1926, Newt Scamander arrives at the Magical Congress of the United States of America with a magically expanded briefcase, which houses a number of dangerous creatures and their habitats. When the creatures escape from the briefcase, it sends the American wizarding authorities after Newt, and threatens to strain even further the state of magical and non-magical relations.
A rare mutation has occurred within the vampire community – The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires.
Two hundred years after Lt. Ripley died, a group of scientists clone her, hoping to breed the ultimate weapon. But the new Ripley is full of surprises … as are the new aliens. Ripley must team with a band of smugglers to keep the creatures from reaching Earth.